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KMID : 0960920030020010029
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Dementia and Neurocognitive Disorders
2003 Volume.2 No. 1 p.29 ~ p.35
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FDG-PET Findings of Semantic Dementia: an Statistical Parametric Mapping Analysis
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Kwon Jay-C.
Kang Keon-Wook
Jeong Jee-H
Lee Byung-Hwa
Jeong Yong
Cho Sang-Soo
Na Duk-Lyul
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Abstract
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Background: Semantic dementia (SD) is a temporal variant of frontotemporal lobar degeneration (FTLD), which is characterized by naming difficulty, decreased comprehension of words, prosopagnosia and object visual agnosia. We report FDG-PET findings of 6 patients with SD that was analyzed by Statistical Parametric Mapping (SPM).
Methods: Six patients fulfilled the diagnostic criteria of SD proposed by consensus on FTLD diagnostic criteria. Brain MRI showed asymmetric temporal atrophies, mainly left antero-inferior temporal cortices in all patients. We performed FDG-PET scan in these patients and 11 normal controls and conducted an SPM analysis to identify brain regions with glucose hypometabolism in SD patients
Results: Visually, FDG-PET images of the six patients showed hypometabolism in bilateral anterior temporal lobes, more severe on the left. Hypometablic brain regions analyzed by SPM method were left fusiform gyrus, middle, inferior temporal gyri and right superior temporal gyrus.
Conclusion: Our results suggest that SD is a degenerative dementia that primarily affects anterior and basal temporal area especially of the left hemisphere.
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KEYWORD
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Semantic dementia, Frontotemporal lobar degeneration, MRI, FDG-PET, SPM
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